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KMID : 0378019640070110047
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New Medical Journal
1964 Volume.7 No. 11 p.47 ~ p.58
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Experimental Studies on the Human Placental Substance
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Abstract
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In 1940, Filatow, ophthalmologist, observed an interesting fact that, when being preserved in optimal hypothermic condition, a piece of the human body tissue liberated "Biogenic Stimulators", active substance which possessed a biogenically stimulating action ´to the living human body tissues. He demonstrated a salutatory effect of enhancing recovery of the body tissues from the various diseased conditions, such as, inflammatory eye diseases, .tuberculosis, obstructive phenomena due to a scar formation, skin diseases, gastric and duodenal peptic ulcers, hypertensive disorders and gynecological inflammatory disorders. However, there was no side effect of using the substance at all.
Author observed promising clinical results in the two groups of patients treated with the placental substance, since Tuly 21, 1958.
The first group of two hundreds patients recieved implantation of the refrigerated human placenta (2^-4 C,for five days), and the second group of a hundred and fifty-eight patients were given orally the boiled water extract of the refrigerated placenta.
For the evaluation of discrepancy of activity between the fresh human placental extract and the refrigerated, between ether and water extract, of fate in heat and acid, and of the character of the effective ingredients of this substance, the following five differently treated materials were used.
(A) Of homogenized refrigerated human placenta (for five days)
1) Water extract at 100C for 30 minutes (PA)
2) The dializate of the PA at 60C (PD)
3) Ether extract at room temperature for 24 hours (PE)
(B) Of homogenized fresh human placenta
4) Water extract at 100C for 30 minutes (NP)
5) Water extract forcibly shaken at room temperature for 30 minutes (NNP) PA and PD promisingly resulted in hypotensive effect, without any significant ECG change, hyperpnea,
capillary dilatation, diuresis, increased peristalsis of the intestine, increased tonus of a non-pregnant
uterus, accelerated growth of Candida albicans and enhancing blood catalase activity and metabolism.
It has been found that a cholinergic inhibitor (atropine), an antihistamine (diphenhydramine), Kolthoff´s
buffer sol. (pH 2.2, 4.0, 8.0 & 12.0), Trypsin and Amylase are without effect on placental factor-induced
rabbit intestine contractions.
NP and NNP did show the similar effects as the former group, yet in much less effect in comparison to the former group. However, in the latter group the potency of the aformentioned actions of the former (NP) appeared stronger than those of the latter (NNP). .
In the ether extract there was practically no pharmacological, micro-biological and biochemical activities of the substance.
In view of the results from the above experimental studies, it can be acertained that there is an active substance in the human placental tissues which is heat-stable, . water-soluble and low molecular, and activity of the refrigerated substance excels the fresh (non-refrigerated) placental substance.
Therefore, in conclusion it is certainly useful and logical to utilize a human placental tissues as an organo-therapy (placento-therapy) after treating in temperature of 2C for five days.
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